The only reversal agent that specifically targets FXa inhibitors1

ANDEXXA® binds to and sequesters FXa inhibitors, allowing native FXa to restore thrombin activity, a necessary step in fibrin and clot formation.*1-4

*ANDEXXA has not been shown to be effective for, and is not indicated for, the treatment of bleeding related to any FXa inhibitors other than apixaban or rivaroxaban.

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ANDEXXA: a modified recombinant FXa protein1

ANDEXXA acts as a FXa decoy that:1,3
  • Binds directly to free-floating FXa inhibitors with high affinity
  • Sequesters FXa inhibitors
  • Rapidly reduces free plasma concentration of FXa inhibitors, neutralizing their anticoagulant effect
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Professional Guidelines

See the standard of care guidelines from American College of Cardiology (ACC), CHEST, and more.

FXa is critical to thrombin generation in the coagulation cascade†1,2,4,5

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An improvement in hemostasis has not been established.1

See how ANDEXXA works

References:
1. Andexxa (prescribing information). Boston, MA: Alexion Pharmaceuticals, Inc.; 2021. 2. Data on file. Alexion Pharmaceuticals, Inc.
3. Siegal DM, Curnutte JT, Connolly SJ, et al. Andexanet alfa for the reversal of factor Xa inhibitor activity. N Engl J Med. 2015;373(25):2413-2424. 4. Morales-Vidal S, Schneck MJ, Flaster M, et al. Direct thrombin inhibitors and factor Xa inhibitors in patients with cerebrovascular disease. Expert Rev Neurother. 2012;12(2):179-190. 5. Lassen MR, Laux V. Emergence of new oral antithrombotics: a critical appraisal of their clinical potential. Vasc Health Risk Manag. 2008;4(6):1373-1386.